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Corticosteroids are medications often used to treat arthritis and related conditions. Results from one multicenter, randomized, placebo-managed research with methylprednisolone hemisuccinate, an intravenous corticosteroid, confirmed a rise in early (at 2 weeks) and late (at 6 months) mortality in sufferers with cranial trauma who were determined not to have other clear indications for corticosteroid remedy.
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Within the literature, a small preliminary examine prompt that using topical agents (urea 40%, fluocinonide 0.05%, and tazarotene 0.1% cream) is efficient; a ≥2-grade enchancment in severity was reported in the majority of sufferers (58%).171 The result of a subsequent section 2 double-blind RCT evaluating these brokers is anticipated.
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